产品货号：
Z18637
中文名称：
HTR1A抗体
英文名称：
Anti-HTR1A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HTR1A Antibody |
| 指标别名 | 5 HT 1A;5 HT1A;5HT1a;ADRB2RL1;ADRBRL1;G 21;HTR1A;Serotonin receptor 1A |
| 克隆性 | Polyclonal |
| 检验物种 | human,rat |
| 应用范围 | WB,IHC |
| 基因名称 | HTR1A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor(404-422aa NKDFQNAFKKIIKCKFCRQ),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 55KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | HTR1A(5-HYDROXYTRYPTAMINE RECEPTOR 1A),also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21,is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin.It is a G protein-coupled receptor(GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission.HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3.The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan.Activation of 5-HT-1A receptors has been demonstrated to impair cognition,learning,and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain.5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1(NK1) receptors and have been shown to inhibit the release of substance P,their endogenous ligand. |
| Uniprot ID | P08908 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | 5-hydroxytryptamine(serotonin) receptor 1A,G protein-coupled |
| 蛋白名全称 | 5-hydroxytryptamine receptor 1A(5-HT-1A/5-HT1A) |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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